Selenicereus grandiflorus is a cactus species originating from the Antilles, Mexico and Central America. The species is commonly referred to as Nightblooming Cereus, Queen of the Night (though these two terms are also used for other species), Large-flowered Cactus, Sweet-Scented Cactus or Vanilla Cactus.

The true species is extremely rare in cultivation. Most of the plants under this name belong to other species or hybrids.